Full profile
| Best for | Historically marketed as a nootropic — not a lawful or safe candidate for this product |
|---|---|
| Evidence grade | Graded Out — Graded out — evaluated and not featured (failed replication or a safety signal) |
| Studied dose range | Not applicable — not a candidate for inclusion. |
| Time to effect | Not applicable. |
| Best form | Not applicable. |
Evidence, honestly graded
Excluded on legal and safety grounds, not just an evidence-strength judgment. The FDA has stated that vinpocetine does not meet the definition of a dietary ingredient under U.S. law, meaning it is not lawfully marketable as a supplement ingredient, and separately issued a 2019 consumer safety alert regarding reproductive harm and possible miscarriage risk. Do not feature.
See the full grading rubric — study type, replication, population match, and dose adequacy — in The Evidence Standard.
Who should avoid it or check first
- Not a lawful dietary ingredient in the U.S. — excluded outright
What to look for on a label
- Documented here for transparency only — not a candidate ingredient under any circumstance.
References
- FDA statement — vinpocetine not a dietary ingredient. FDA has stated vinpocetine does not meet the definition of a dietary ingredient, excluding it from lawful marketing as a supplement ingredient in the U.S. Basis for the Graded Out status. Educational, regulatory background.
- FDA 2019 consumer safety alert — vinpocetine and reproductive harm. FDA safety alert regarding reproductive harm and possible miscarriage risk associated with vinpocetine use. Educational.
Primary citations for some entries above are still being compiled; those without a linked identifier are editorial summaries of the wider literature.
Grades and studied doses are our conservative reading of the human research, shown for education. They are not product claims, and a studied dose is not a recommended dose.
See how Vinpocetine compares on grade, dose, and goal in the Evidence Explorer.