Full profile
| Best for | Historically marketed as a nootropic; not a lawful or safe candidate for this product |
|---|---|
| Evidence grade | Graded out: evaluated and not featured (failed replication or a safety signal) |
| Studied dose range | Not applicable: not a candidate for inclusion. |
| Time to effect | Not applicable. |
| Best form | Not applicable. |
Evidence, honestly graded
Excluded on legal and safety grounds, not just an evidence-strength judgment. The FDA has stated that vinpocetine does not meet the definition of a dietary ingredient under U.S. law, meaning it is not lawfully marketable as a supplement ingredient, and separately issued a 2019 consumer safety alert regarding reproductive harm and possible miscarriage risk. Do not feature.
See the full grading rubric (study type, replication, population match, and dose adequacy) in The Evidence Standard.
Who should avoid it or check first
- Not a lawful dietary ingredient in the U.S.; excluded outright
What to look for on a label
- Documented here for transparency only, not a candidate ingredient under any circumstance.
References
- FDA statement: vinpocetine not a dietary ingredient. FDA has stated vinpocetine does not meet the definition of a dietary ingredient, excluding it from lawful marketing as a supplement ingredient in the U.S. Basis for the Graded Out status. Educational, regulatory background.
- FDA 2019 consumer safety alert: vinpocetine and reproductive harm. FDA safety alert regarding reproductive harm and possible miscarriage risk associated with vinpocetine use. Educational.
Entries above without a linked identifier are either editorial summaries of a wider body of literature or references to a named authority (a regulator or government monograph) cited by name rather than by a single paper.
Grades and studied doses are our conservative reading of the human research, shown for education. They are not product claims, and a studied dose is not a recommended dose.
Revision history
Every change to this ingredient's evidence status, dated and explained. The full cross-library log lives at Evidence Updates.
- 2026-07-07Graded out
Initial profile published straight into Graded Out on legal and safety grounds: the FDA has stated vinpocetine is not a lawful dietary ingredient and flagged a reproductive-harm risk.
See how Vinpocetine compares on grade, dose, and goal in the Evidence Explorer.