Full profile
| Also known as | Longvida, Curcuminoids |
|---|---|
| Best for | Working memory support · Mood support |
| Evidence grade | Grade B — Moderate — several human trials, some mixed results |
| Studied dose range | 400 mg/day of Longvida (delivering roughly 80 mg curcuminoids). |
| Time to effect | Some acute mood effects; working-memory benefit studied over 4 weeks. |
| Best form | Longvida or an equivalent lipidated/phospholipid-complexed curcumin — plain turmeric powder has poor bioavailability. |
Evidence, honestly graded
Cox 2015 and a 2020 follow-up (same research group, healthy older adults) found modest working-memory and mood/fatigue benefits with the Longvida lipidated formulation versus placebo. Capped at B because the positive trial base is internal (same-group) replication rather than independent cross-sponsor replication, and the studied population skews 50+ rather than a broad healthy-adult range.
See the full grading rubric — study type, replication, population match, and dose adequacy — in The Evidence Standard.
Side effects
- Generally well tolerated
- Mild GI upset in some users
Who should avoid it or check first
- Gallbladder disease without clinician guidance
- Scheduled for surgery (theoretical bleeding risk)
Interactions
- Theoretical antiplatelet effect — caution with anticoagulants — discuss with a clinician
Stacks well with
- Omega-3
What to look for on a label
- Specify the bioavailability-enhanced form (e.g. Longvida) and its curcuminoid delivery — plain turmeric extract does not match the studied material.
References
- Cox 2015, J Psychopharmacology — Longvida curcumin RCT. Healthy older adults; acute and 4-week dosing improved working memory and mood/fatigue measures versus placebo. Educational, not a product claim.
- Cox 2020 — Longvida curcumin follow-up. Same research group; broadly replicated the working-memory and mood signal in an older-adult sample. Internal (same-group) replication — noted as the honest caveat behind the B grade rather than A.
Primary citations for some entries above are still being compiled; those without a linked identifier are editorial summaries of the wider literature.
Grades and studied doses are our conservative reading of the human research, shown for education. They are not product claims, and a studied dose is not a recommended dose.
See how Curcumin (lipidated) compares on grade, dose, and goal in the Evidence Explorer.