Full profile
| Also known as | Mangifera indica leaf extract, Mangiferin |
|---|---|
| Best for | Acute alertness without stimulant activation · Attention accuracy on demanding tasks |
| Evidence grade | Grade B — Moderate — several human trials, some mixed results |
| Studied dose range | 100–300 mg/day; 300 mg is the most-studied acute dose. |
| Time to effect | Acute — effects studied within 1–2 hours of a single dose. |
| Best form | Zynamite (Mangifera indica leaf extract standardized to ~60% mangiferin). |
Evidence, honestly graded
Graded B for the acute-use claim specifically; chronic daily use is Emerging, not yet supported by repeated-dosing human trials. Gutiérrez-Hellín 2020 (Nutrients, PMC7468873) gave 70 healthy adults 300 mg Zynamite and found improved attention accuracy and episodic memory versus placebo, without the cardiovascular activation seen with stimulants.
See the full grading rubric — study type, replication, population match, and dose adequacy — in The Evidence Standard.
Side effects
- Generally well tolerated
- Limited long-term human safety data given the acute-focused trial base
Who should avoid it or check first
- Pregnant or breastfeeding without clinician guidance (limited data)
Interactions
- COMT-inhibition mechanism — caution combining with stimulant medications, MAOIs, L-DOPA, or L-tyrosine supplementation — discuss with a clinician
Stacks well with
- L-Theanine
Use caution stacking with
- L-Tyrosine at high dose (overlapping catecholamine-pathway mechanism)
What to look for on a label
- Specify the branded Zynamite extract and its mangiferin standardization — plain "mango leaf extract" doesn't guarantee the studied material.
- Position as acute/single-dose alertness support; chronic-use claims outrun the current evidence.
References
- Gutiérrez-Hellín 2020, Nutrients — Zynamite acute attention RCT. n=70 healthy adults; single 300 mg dose improved attention accuracy and episodic memory versus placebo, without cardiovascular activation. PMC7468873. Educational, not a product claim.
Primary citations for some entries above are still being compiled; those without a linked identifier are editorial summaries of the wider literature.
Grades and studied doses are our conservative reading of the human research, shown for education. They are not product claims, and a studied dose is not a recommended dose.
See how Zynamite compares on grade, dose, and goal in the Evidence Explorer.