Full profile
| Also known as | Uridine monophosphate, UMP |
|---|---|
| Best for | Mechanistic pairing with choline sources and DHA (theoretical) |
| Evidence grade | Emerging — Emerging — mostly preclinical or preliminary human data |
| Studied dose range | ~500 mg–2 g/day in available human research. |
| Time to effect | Not established in healthy adults. |
| Best form | Uridine monophosphate is the most commonly studied form. |
Evidence, honestly graded
Human data is biomarker-level: 31P-MRS studies show increased brain phospholipid precursors with uridine supplementation. The cognition data that exists comes from animal studies or from the Souvenaid stack (uridine + DHA + choline) trialed in prodromal Alzheimer's patients — not from healthy adults, and not from uridine alone. Worth tracking: this is the most common ingredient serious competitor formulas carry that this brand currently doesn't, but the healthy-adult evidence isn't there yet.
See the full grading rubric — study type, replication, population match, and dose adequacy — in The Evidence Standard.
Side effects
- Generally well tolerated in available trials
- Long-term healthy-adult safety data is limited
Who should avoid it or check first
- Pregnant or breastfeeding without clinician guidance (limited data)
Interactions
- Limited interaction data — discuss with a clinician if on medication
Stacks well with
- Citicoline
- Omega-3 (mechanistic pairing, not clinically proven as a combination)
What to look for on a label
- Do not imply the Souvenaid prodromal-Alzheimer's cognition data applies to healthy adults — it doesn't, and the populations are not comparable.
References
- 31P-MRS studies — uridine and brain phospholipid precursors. Human biomarker studies show increased brain phospholipid precursor levels with uridine supplementation — a mechanistic signal, not a cognition-outcome trial. Educational.
- Souvenaid (uridine + DHA + choline) trials in prodromal Alzheimer's. Cognitive outcome data exists for this combination product in a prodromal-Alzheimer's population — not healthy adults, and not uridine alone. Cited for honest context, not as supporting evidence for this product's use case.
Primary citations for some entries above are still being compiled; those without a linked identifier are editorial summaries of the wider literature.
Grades and studied doses are our conservative reading of the human research, shown for education. They are not product claims, and a studied dose is not a recommended dose.
See how Uridine compares on grade, dose, and goal in the Evidence Explorer.