Full profile
| Also known as | Trans-resveratrol, Resvida |
|---|---|
| Best for | Cerebral blood flow support · Verbal memory support |
| Evidence grade | Grade B — Moderate — several human trials, some mixed results |
| Studied dose range | 150 mg/day (commonly split as 75 mg twice daily) of trans-resveratrol. |
| Time to effect | Acute cerebral-blood-flow effect within hours; memory trials ran up to 24 months. |
| Best form | Resvida or an equivalent trans-resveratrol extract with a stated purity. |
Evidence, honestly graded
Kennedy 2010 found an acute single dose improved cerebral blood flow in healthy adults, and postmenopausal-women RCTs — including a 24-month trial — extended the signal to memory measures over time. Capped at B because the strongest and longest human trials are concentrated in postmenopausal women studied by one research group, which limits how confidently the finding generalizes to a broader healthy-adult population.
See the full grading rubric — study type, replication, population match, and dose adequacy — in The Evidence Standard.
Side effects
- Generally well tolerated
- Mild GI upset at higher doses
Who should avoid it or check first
- Pregnant or breastfeeding without clinician guidance
- Hormone-sensitive conditions without clinician review (phytoestrogen-adjacent activity has been studied)
Interactions
- Possible interaction with CYP-metabolized drugs via cytochrome P450 modulation — discuss with a clinician
Stacks well with
- Omega-3
What to look for on a label
- Specify "trans-resveratrol" and its purity — the trans isomer is the studied form.
References
- Kennedy 2010 — acute resveratrol cerebral blood flow RCT. Single dose improved cerebral blood flow in healthy adults versus placebo. Educational, not a product claim.
- Postmenopausal resveratrol RCTs, including a 24-month trial. Extended the cerebral blood flow and memory signal in postmenopausal women over a longer dosing period. Concentrated in one research group — the honest caveat behind the B grade rather than A.
Primary citations for some entries above are still being compiled; those without a linked identifier are editorial summaries of the wider literature.
Grades and studied doses are our conservative reading of the human research, shown for education. They are not product claims, and a studied dose is not a recommended dose.
See how Resveratrol compares on grade, dose, and goal in the Evidence Explorer.
